Ohio State vs. Indiana Predictions: 6 Bold Picks, Score Predictions and Keys to Victory

Ohio State Buckeyes cornerback Jermaine Mathews Jr. (7) and defensive back Cam Calhoun (18) hit Maryland Terrapins wide receiver Jayden Kitchens (17) during the NCAA football game at Ohio Stadium in Columbus on Oct. 10, 2026. Adam Cairns/Columbus Dispatch, USA TODAY Network Via Reuters Co
October 16, 2026

Blake Biscardi and Grant Kincaid make six bold predictions for Ohio State vs. Indiana, pick the winner and over/under, and break down the keys to victory in Bloomington. Ohio State has a chance to answer one of the biggest questions surrounding its program as it travels to Bloomington to face Indiana on Saturday. The Buckeyes and Hoosiers meet in a top-five showdown and a rematch of last season’s Big Ten…

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Ohio State vs. Indiana: What Each Team’s Running Game Could Look Like on Saturday

October 16, 2026

Ohio State vs. Indiana will feature a top-five matchup with two running games that could decide the game. Ohio State and Indiana are set for their top-five clash Saturday in Bloomington, their first matchup since last season’s Big Ten Championship. Indiana won 13-10 in a low-scoring affair and managed a few more ground-game plays than Ohio State to pull out the win. Both teams’ rushing attacks look very different than…

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Ohio State vs. Indiana: Buckeyes Travel to Bloomington for Chance at Redemption and Monumental Win

Ohio State quarterback Julian Sayin looks to throw a pass against Maryland during the first half of an NCAA college football game, Saturday, Oct. 10, 2026, in Columbus, Ohio. (AP Photo/Jay LaPrete)
October 15, 2026

Ohio State travels to Bloomington against the undefeated Indiana Hoosiers in a rematch of the 2025 Big Ten Championship Game. Ohio State faces off against the undefeated Indiana Hoosiers in a rematch of the 2025 Big Ten Championship game. Here’s a preview of Indiana’s team and the key matchups to watch: Opponent Profile Curt Cignetti’s Hoosiers enter Saturday’s matchup on a 22-game winning streak. The streak is the third longest…

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How Will Ohio State’s Offensive Line Handle Indiana’s Defense Without Austin Siereveld?

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October 15, 2026

Ohio State reshuffles its offensive line against Indiana as Phillip Daniels returns from injury, Gabe VanSickle starts at guard, and Julian Sayin faces defensive pressure. Ohio State will start a new offensive line against Indiana, with Austin Siereveld ruled out and Phillip Daniels returning from injury. Gabe VanSickle will start at right guard, while Ian Moore takes left tackle and Luke Montgomery lines up at left guard. The expected starting…

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Buckeyes in the NFL: Former Ohio State Players Shine in Week 5 as Arvell Reese Dominates

Arvell Reese rushes the quarterback during the Giants-Vikings preseason game on Aug. 15, 2026. Getty Images
October 15, 2026

Former Ohio State Buckeyes shine in NFL Week 5 as Arvell Reese, Sonny Styles, Jack Sawyer and C.J. Stroud headline standout performances across the league. Former Ohio State football stars continued to make their mark in Week 5 of the NFL, led by rookie linebacker Arvell Reese’s standout performance for the New York Giants. Reese recorded nine tackles and a sack, while Sonny Styles posted a team-high 13 tackles for…

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What Will Ohio State’s Offensive Line Look Like Against Indiana?

Image Credit: Ohio State Football
October 14, 2026

Ryan Day expects Phillip Daniels back as Ohio State’s offensive line prepares to face Indiana’s disruptive defensive front in a critical Big Ten matchup. Ohio State’s offensive line faces its toughest test of the season Saturday against Indiana, and Ryan Day is still working through personnel combinations to protect Julian Sayin and establish the running game. The Buckeyes expect to get starting right tackle Phillip Daniels back after he missed…

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Ohio State Buckeyes at Indiana Hoosiers: Week 7 Matchup Preview and Odds Analysis

October 14, 2026

Ohio State visits Indiana in Week 7. Get game details, kickoff info, spread analysis, and key players to watch in this Big Ten clash. The No. 4-ranked Ohio State Buckeyes travel to Bloomington this Saturday at noon to face the No. 5-ranked Indiana Hoosiers in Week 7. The Buckeyes enter 5-1 overall with Big Ten wins over Illinois, at Iowa, and at Maryland. The Hoosiers enter the contest undefeated at…

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Ohio State QB Julian Sayin’s Growth Faces a Test Against Indiana’s Pass Rush

Ohio State Buckeyes quarterback Julian Sayin (10) scrambles during the first half of the Big Ten Conference championship game against the Indiana Hoosiers at Lucas Oil Stadium in Indianapolis on Dec. 6, 2025. Adam Cairns/Columbus Dispatch, Adam Cairns/Columbus Dispatch / USA TODAY
October 13, 2026

Julian Sayin’s growth will be tested against Indiana’s pass rush as Ohio State prepares for a rematch of last season’s Big Ten Championship. Julian Sayin will face the team that gave him his most difficult night of the 2025 season when Ohio State travels to Indiana on Saturday. The rematch will be a different challenge for the Buckeyes’ quarterback, who has spent the offseason and first six games improving his…

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Ohio State Has Had Indiana Circled Since the Big Ten Championship Game

Copyright: © 2025 Adam Cairns/The Columbus Dispatch/USA TODAY Network | Creator: Adam Cairns/Columbus Dispatch
October 13, 2026

Ohio State enters its Top-5 matchup with Indiana motivated by last year’s Big Ten Championship loss as the Buckeyes prepare for a road test in Bloomington. Ohio State has spent nearly a year thinking about its loss to Indiana in the Big Ten Championship Game. On Saturday, the Buckeyes will get their first chance to respond. “They took something from us that we really wanted,” defensive tackle Eddrick Houston said….

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Can Ohio State Be Trusted Against Indiana and in Big Games Down the Stretch?

Ohio State Buckeyes wide receiver Jeremiah Smith (4) scores a touchdown past Maryland Terrapins defensive back Messiah Delhomme (33) during the NCAA football game at Ohio Stadium in Columbus on Oct. 10, 2026. Adam Cairns/Columbus Dispatch
October 12, 2026

After four straight wins, including a road victory at Iowa, can Ohio State be trusted against Indiana and the toughest remaining schedule in college football? Which version of Ohio State better represents the team: the one that dominated the first three quarters against Texas or the one that surrendered a 20-point lead in the fourth? Ryan Day frequently talks about trust when discussing playing time for transfers and young players….

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